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A Concise Route to MK-4482 (EIDD-2801)

Natarajan Vasudevan, Grace P. Ahlqvist, Catherine P. McGeough, Dinesh J. Paymode, Flavio S. P. Cardoso, Tobias Lucas, Jule-Phillip Dietz, Till Opatz, Timothy F. Jamison, B. Frank Gupton, David Snead

Version 1 posted 19 August 2020

1,397

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Organic Chemistry

Working Paper

A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2

Vijayagopal Gopalsamuthiram, Corshai Williams, Jeffrey Noble, Timothy F. Jamison, B. Frank Gupton, David Snead

Version 1 posted 09 September 2020

1,510

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Organic Chemistry

Working Paper

High Yielding, Multigram-Scale Synthesis of TBAJ-876 Fragment, 876A-B

Pankaj V. Khairnar, Chiranjeevi Barreddi, Nakul Telang, Saeed Ahmad, B. Frank Gupton, Douglas A. Klumpp, Michel C. Nuckols

Version 2 posted 24 April 2024

207

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Organic Chemistry

Working Paper

Towards a Practical, Non-enzymatic Process for Molnupiravir from Cytidine

Vijayagopal Gopalsamuthiram, Appasaheb L. Kadam, Jeffrey Noble, David Snead, Corshai Williams, Timothy F. Jamison, Chris Senanayake, Ajay Yadaw, Sarabindu Roy, Gopal Sirasani, B. Frank Gupton, Justina Burns, Daniel W. Cook, Rodger W. Stringham, Saeed Ahmad, Rudy Krack

Version 1 posted 08 June 2021

2,215

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2

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Organic Chemistry

Working Paper

Facile and Scalable Methodology for the Pyrrolo[2,1-f][1,2,4]triazine of Remdesivir

Sarabindu Roy, Ajay Yadaw, Subho Roy, Gopal Sirasani, Joseph D. Armstrong, B. Frank Gupton, Chris Senanayake, David Snead

Version 1 posted 25 February 2021

647

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1

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Organic Chemistry

Working Paper

Practical synthesis of 7-bromo-4-chloro-1H-indazol-3-amine: an important intermediate to Lenacapavir

Naeem Asad, Michael Lyons, Shirley Muniz Machado Rodrigues, Justina Burns, Thomas Roper, George Laidlaw, Saeed Ahmad, B. Frank Gupton, Douglas Klumpp, limei jin

Version 1 posted 30 April 2024

90

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Organic Chemistry

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Development of New Catalytic Asymmetric Routes towards a Cost-Driving Building Block of Nirmatrelvir

Robert Szpera, Shanjun Huang, Harriet A. M. Fenton, William Waddington, Adam E. S. Gymer, Ian Moses, Julia Buck, Heather Ingram, Steven J. Fussell, Robert Walton, Charles S. Shanahan, Sarah L. Aleshire, Juliana M. S. Robey, Hanuman P. Kalmode, Michel C. Nuckols, Nageswara R. Kalikinidi, Venumadhav Janganati, Sipak Joyasawal, Chanaka M. Amarasekarage, Chris Senanayake, B. Frank Gupton

Version 1 posted 31 January 2024

300

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Organic Chemistry

Working Paper

Efforts to Develop a Cost-Effective and Scalable Synthetic Process for Nirmatrelvir

Charles S. Shanahan, Appasaheb L. Kadam, Barreddi Chiranjeevi, Aline A. Nunes, Aravindan Jayaraman, Saeed Ahmad, Sarah L. Aleshire, Kai O. Donsbach, B. Frank Gupton, Michel C. Nuckols

Version 1 posted 08 August 2022

957

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5

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Organic Chemistry

Working Paper

Toward Secure Supply of Remdesivir via a 2-Pot Triazine Synthesis: Supply Centered Synthesis

Dinesh J. Paymode, Flavio S. P. Cardoso, Joshua D. Sieber, John W. Tomlin, Daniel W. Cook, Justina Burns, Rodger W. Stringham, B. Frank Gupton, David Snead, Toolika Agrawal

Version 1 posted 10 August 2020

847

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2

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Organic Chemistry

Working Paper

An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines

Brenden Derstine, John W. Tomlin, Cheryl Peck, Jule-Phillip Dietz, Brenden Herrera, Flavio S. P. Cardoso, Dinesh J. Paymode, Andrew C. Yue, Anthony J. Arduengo III, Till Opatz, David R. Snead, Rodger W. Stringham, D. Tyler McQuade, B. Frank Gupton

Version 1 posted 26 February 2020

2,073

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15 results in B. Frank Gupton in Authors: B. Frank Gupton

A Concise Route to MK-4482 (EIDD-2801)

A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2

High Yielding, Multigram-Scale Synthesis of TBAJ-876 Fragment, 876A-B

Towards a Practical, Non-enzymatic Process for Molnupiravir from Cytidine

Facile and Scalable Methodology for the Pyrrolo[2,1-f][1,2,4]triazine of Remdesivir

Practical synthesis of 7-bromo-4-chloro-1H-indazol-3-amine: an important intermediate to Lenacapavir

Development of New Catalytic Asymmetric Routes towards a Cost-Driving Building Block of Nirmatrelvir

Efforts to Develop a Cost-Effective and Scalable Synthetic Process for Nirmatrelvir

Toward Secure Supply of Remdesivir via a 2-Pot Triazine Synthesis: Supply Centered Synthesis

An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines

15 results in Authors: B. Frank Gupton